Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii
نویسندگان
چکیده
منابع مشابه
Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii
The apical complex of Toxoplasma gondii is widely believed to serve essential functions in both invasion of its host cells (including human cells), and in replication of the parasite. The understanding of apical complex function, the basis for its novel structure, and the mechanism for its motility are greatly impeded by lack of knowledge of its molecular composition. We have partially purified...
متن کاملSynchronous invasion of host cells by Toxoplasma gondii.
Synchronous invasion of host cells by Toxoplasma gondii B.F.C. Kafsack a,∗, C. Beckers b, V.B. Carruthers a a W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205-1918, USA b Division of Geographic Medicine, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35...
متن کاملThe Apical Complex Provides a Regulated Gateway for Secretion of Invasion Factors in Toxoplasma
The apical complex is the definitive cell structure of phylum Apicomplexa, and is the focus of the events of host cell penetration and the establishment of intracellular parasitism. Despite the importance of this structure, its molecular composition is relatively poorly known and few studies have experimentally tested its functions. We have characterized a novel Toxoplasma gondii protein, RNG2,...
متن کامل'The glideosome': a dynamic complex powering gliding motion and host cell invasion by Toxoplasma gondii.
Motion is an intrinsic property of all living organisms, and each cell displays a variety of shapes and modes of locomotion. How structural proteins support cellular movement and how cytoskeletal dynamics and motor proteins are harnessed to generate order and movement are among the fundamental and not fully resolved questions in biology today. Protozoan parasites belonging to the Apicomplexa ar...
متن کاملA mathematical model for within-host Toxoplasma gondii invasion dynamics.
Toxoplasma gondii (T. gondii) is a protozoan parasite that infects a wide range of intermediate hosts, including all mammals and birds. Up to 20% of the human population in the US and 30% in the world are chronically infected. This paper presents a mathematical model to describe intra-host dynamics of T. gondii infection. The model considers the invasion process, egress kinetics, interconversio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2006
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.0020013